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Comment
. 2007 Dec 14;318(5857):1722; author reply 1722.
doi: 10.1126/science.1149590.

Comment on "Tumor growth need not be driven by rare cancer stem cells"

James A Kennedy  1 , Frédéric Barabé, Armando G Poeppl, Jean C Y Wang, John E Dick
Affiliations
Comment

Comment on "Tumor growth need not be driven by rare cancer stem cells"

James A Kennedy et al. Science. .

Abstract

Kelly et al. (Brevia, 20 July 2007, p. 337) questioned xenotransplant experiments supporting the cancer stem cell (CSC) hypothesis because they found a high frequency of leukemia-initiating cells (L-IC) in some transgenic mouse models. However, the CSC hypothesis depends on prospective purification of cells with tumor-initiating capacity, irrespective of frequency. Moreover, we found similar L-IC frequencies in genetically comparable leukemias using syngeneic or xenogeneic models.

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