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Case Reports
. 2007 Dec;21(12):835-7.
doi: 10.1155/2007/737640.

Refractory Crohn's disease of the vulva treated with infliximab: a case report

S Makhija  1 , M Trotter, E Wagner, S Coderre, R Panaccione
Affiliations
Case Reports

Refractory Crohn's disease of the vulva treated with infliximab: a case report

S Makhija et al. Can J Gastroenterol. 2007 Dec.

Abstract
in English, French

Crohn's disease (CD) is a chronic relapsing and remitting inflammatory disorder of the gastrointestinal tract. The common presentation includes abdominal pain, abdominal cramping and diarrhea. Many patients may exhibit systemic symptoms of fever and weight loss. Approximately 20% to 40% of patients will experience extraintestinal manifestations that involve the eyes, skin and joints. Women may experience a variety of gynecological manifestations, including vulvovaginal involvement, which is often not recognized and also difficult to treat. A case of refractory vulvovaginal CD is presented and the literature of gynecological manifestations of CD and its treatment are reviewed.

La maladie de Crohn (MC) est une maladie inflammatoire chronique cyclique du tractus digestif. Le tableau le plus courant inclut : douleurs abdominales, crampes abdominales et diarrhée. De nombreux patients peuvent manifester des symptômes systémiques de fièvre et de perte de poids. Environ 20 % à 40 % des patients éprouveront des manifestations extraintestinales affectant les yeux, la peau et les articulations. Les femmes peuvent en manifester des signes gynécologiques, notamment l’atteinte vulvo-vaginale, souvent méconnue et difficile à traiter. Les auteurs présentent ici un cas de MC vulvo-vaginale réfractaire et passent en vue la littérature sur les manifestations gynécologiques de la MC et leur traitement.

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Figures

Figure 1)
Figure 1)
Vulvar biopsy, showing loose, ill-defined, granulomatous inflammation in the dermis, consistent with cutaneous involvement by Crohn’s disease
Figure 2)
Figure 2)
Recurrent Crohn’s disease at colorectal anastamosis
Figure 3)
Figure 3)
Internal os of fistula rectum
Figure 4)
Figure 4)
Vulvar biopsy postinfliximab therapy showing no evidence of dermal granulomatous inflammation
See this image and copyright information in PMC

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