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. 2008 Feb 1;18(3):1116-9.
doi: 10.1016/j.bmcl.2007.11.126. Epub 2007 Dec 5.

Synthesis and anti-HIV activity of 2'-fluorine modified nucleoside phosphonates: analogs of GS-9148

Richard L Mackman  1 , Kuei-Ying Lin, Constantine G Boojamra, Hon Hui, Janet Douglas, Deborah Grant, Oleg Petrakovsky, Vidya Prasad, Adrian S Ray, Tomas Cihlar
Affiliations

Synthesis and anti-HIV activity of 2'-fluorine modified nucleoside phosphonates: analogs of GS-9148

Richard L Mackman et al. Bioorg Med Chem Lett. .

Abstract

Modified purine analogs of GS-9148 [5-(6-amino-purin-9-yl)-4-fluoro-2,5-dihydro-furan-2-yloxymethyl]-phosphonic acid (2'-Fd4AP) were synthesized and their anti-HIV potency evaluated. The antiviral activity of guanosine analog (2'-Fd4GP) was comparable that of to 2'-Fd4AP in MT-2 cells, but selectivity was reduced.

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