doi: 10.1016/j.tcb.2007.10.004.
Epub 2007 Dec 20.
Sunburned skin activates inflammasomes
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- PMID: 18083030
- DOI: 10.1016/j.tcb.2007.10.004
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Sunburned skin activates inflammasomes
Trends Cell Biol.
2008 Jan.
Abstract
Ultraviolet (UV) irradiation injures the epidermis, resulting in sunburn and inflammation. UV-irradiated keratinocytes secrete interleukin-1beta through a caspase-1-dependent mechanism. In seeking a link between UV-irradiation and caspase-1 activation, a prominent role for the NOD-like receptor (NLR) family of innate immunity proteins was discovered recently. NLRs activate caspases through the assembly of macromolecular complexes called 'inflammasomes.' Although the mechanism by which UV-irradiation activates inflammasomes remains obscure, these recent findings shed light on NLRs as intermediaries between cell injury and inflammation.
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