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Comment
. 2007 Dec 14;131(6):1044-6.
doi: 10.1016/j.cell.2007.11.030.

A seminal finding for understanding HIV transmission

Nadia R Roan  1 , Warner C Greene
Affiliations
Free article
Comment

A seminal finding for understanding HIV transmission

Nadia R Roan et al. Cell. .
Free article

Abstract

Although the worldwide incidence of HIV infection is high, the retrovirus displays a surprisingly low infectivity in vitro. As a potential explanation for this discrepancy, Münch et al. (2007) now identify and characterize a factor found in human semen that under certain conditions can enhance HIV infectivity by more than 100,000-fold.

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Comment on

  • Semen-derived amyloid fibrils drastically enhance HIV infection.
    Münch J, Rücker E, Ständker L, Adermann K, Goffinet C, Schindler M, Wildum S, Chinnadurai R, Rajan D, Specht A, Giménez-Gallego G, Sánchez PC, Fowler DM, Koulov A, Kelly JW, Mothes W, Grivel JC, Margolis L, Keppler OT, Forssmann WG, Kirchhoff F. Münch J, et al. Cell. 2007 Dec 14;131(6):1059-71. doi: 10.1016/j.cell.2007.10.014. Cell. 2007. PMID: 18083097

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