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Review
. 2007 Dec 14;131(6):1047-58.
doi: 10.1016/j.cell.2007.11.028.

Calcium signaling

David E Clapham  1
Affiliations
Free article
Review

Calcium signaling

David E Clapham. Cell. .
Free article

Abstract

Calcium ions (Ca(2+)) impact nearly every aspect of cellular life. This review examines the principles of Ca(2+) signaling, from changes in protein conformations driven by Ca(2+) to the mechanisms that control Ca(2+) levels in the cytoplasm and organelles. Also discussed is the highly localized nature of Ca(2+)-mediated signal transduction and its specific roles in excitability, exocytosis, motility, apoptosis, and transcription.

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