Dual role of the activated epidermal growth factor receptor in renal tubular cells during stress
- PMID: 18084262
- DOI: 10.1038/sj.ki.5002583
Dual role of the activated epidermal growth factor receptor in renal tubular cells during stress
Abstract
The paper by Sarro et al. raises the therapeutically important possibility that activation of the epidermal growth factor receptor (EGFR) after proximal tubule injury serves an unexpected death function and the EGFR-mediated survival signaling can be restored by identification of parallel and interacting pathways.
Comment on
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Phosphoinositide 3-kinase inhibitors protect mouse kidney cells from cyclosporine-induced cell death.Kidney Int. 2008 Jan;73(1):77-85. doi: 10.1038/sj.ki.5002638. Epub 2007 Oct 24. Kidney Int. 2008. PMID: 17960138
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