doi: 10.1038/ng.2007.52.
Epub 2007 Dec 16.
Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis
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- PMID: 18084291
- DOI: 10.1038/ng.2007.52
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Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis
Nat Genet.
2008 Jan.
Abstract
We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.
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