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. 2008 Jan;40(1):29-31.
doi: 10.1038/ng.2007.52. Epub 2007 Dec 16.

Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis

Michael A van Es  1 , Paul W J van Vught, Hylke M Blauw, Lude Franke, Christiaan G J Saris, Ludo Van den Bosch, Sonja W de Jong, Vianney de Jong, Frank Baas, Ruben van't Slot, Robin Lemmens, Helenius J Schelhaas, Anna Birve, Kristel Sleegers, Christine Van Broeckhoven, Jennifer C Schymick, Bryan J Traynor, John H J Wokke, Cisca Wijmenga, Wim Robberecht, Peter M Andersen, Jan H Veldink, Roel A Ophoff, Leonard H van den Berg
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Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis

Michael A van Es et al. Nat Genet. 2008 Jan.

Abstract

We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.

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