Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Jan;24(1):101-8.
doi: 10.1007/s10103-007-0529-8. Epub 2007 Dec 15.

Impact of intense pulse light irradiation on BALB/c mouse skin-in vivo study on collagens, matrix metalloproteinases and vascular endothelial growth factor

Affiliations

Impact of intense pulse light irradiation on BALB/c mouse skin-in vivo study on collagens, matrix metalloproteinases and vascular endothelial growth factor

Dan Luo et al. Lasers Med Sci. 2009 Jan.

Abstract

Our aim was to investigate the effects of intense pulsed light (IPL) on collagen expression in BALB/c mouse skin and confirm its relative molecular mechanisms. The dorsal skin of BALB/c mice was irradiated by IPL. Before treatment and from 1 day to 8 weeks (1 day, 3 days, 5 days, 1 week, 2 weeks, 3 weeks, 4 weeks, 6 weeks and 8 weeks) after treatment, the irradiated skin specimens were examined. The histology showed dermis thickening, accompanied with increased collagen and better organization. After IPL irradiation from 2 W up to 8 W, the staining of collagen types I and III in the IPL-treated groups was stronger than in the sham groups (P < 0.05), and the mRNA expression levels of the procollagen types I and III had also increased (P < 0.05). The up-regulation effects of IPL irradiation were time-dependent. The mRNA expression levels of matrix metalloproteinase (MMP)-1 and MMP-2 decreased progressively after IPL irradiation at 2 W up to 8 W (P < 0.05), and this down-regulation effect of IPL was also time-dependent. However, the mRNA expression of vascular endothelial growth factor (VEGF) had shown no obvious change by the end of the experiment (P > 0.05). Taking these factors together, we can conclude that IPL irradiation can not only enhance new collagen production, but also decrease collagen degradation in photo-rejuvenation mechanisms in mouse skin.

PubMed Disclaimer

Similar articles

Cited by

References

    1. J Cutan Laser Ther. 2000 Jun;2(2):59-61 - PubMed
    1. Photodermatol Photoimmunol Photomed. 2000 Dec;16(6):239-44 - PubMed
    1. Dermatol Surg. 2001 Jul;27(7):627-31; discussion 632 - PubMed
    1. Arch Dermatol Res. 2000 Jan;292(1):27-31 - PubMed
    1. Dermatol Surg. 2000 Sep;26(9):835-42; discussion 843 - PubMed

LinkOut - more resources