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Review
. 2007 Dec;334(6):441-3.
doi: 10.1097/MAJ.0b013e3180f60bc4.

Sarcoidosis associated with an elevated serum CA 125 level: description of a case and a review of the literature

Meena Kalluri  1 , Marc A Judson
Affiliations
Review

Sarcoidosis associated with an elevated serum CA 125 level: description of a case and a review of the literature

Meena Kalluri et al. Am J Med Sci. 2007 Dec.

Abstract

Background and aim: CA 125 is a glycoprotein expressed by a variety of tissues of mesothelial origin. It has classically been associated with ovarian carcinoma. It has also been reported to be elevated in certain granulomatous conditions. We describe a patient with sarcoidosis and an elevated serum CA 125 level and review the medical literature on this topic.

Methods: We describe a patient with active sarcoidosis and an elevated serum CA 125 level at our institution. A search of medical databases revealed 4 additional cases of sarcoidosis associated with elevated serum CA 125 levels.

Results: All 5 patients (our patient and the 4 found in medical databases) were female. Four of the 5 presented with abdominal symptoms or weight loss. Four of the 5 patients had evidence of peritoneal sarcoidosis. Three patients required treatment and their serum CA 125 levels declined.

Conclusions: Peritoneal sarcoidosis may "mimic" ovarian carcinoma in that it may present with peritoneal or abdominal findings and an elevated serum CA 125 level.

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