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Review
. 2008 Jun;34(3):338-44.
doi: 10.1007/s12016-007-8043-0.

The role of CD4+CD25+ T regulatory cells in autoimmune diseases

E Toubi  1
Affiliations
Review

The role of CD4+CD25+ T regulatory cells in autoimmune diseases

E Toubi. Clin Rev Allergy Immunol. 2008 Jun.

Abstract

Among the several mechanisms that play role in maintaining peripheral self-tolerance is the existence of a unique CD4+CD25+ population of naturally occurring regulatory T (Treg) cells that actively prevent both the activation and the effector function of autoreactive T cells that have escaped different mechanisms of tolerance. Many studies have shown the benefit of targeting this cell population by restoring self-tolerance. Therapies that could possibly increase the suppressive ability of T regulatory cells were proven to improve that course of autoimmune diseases.

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References

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