An HIV/AIDS Prophylactic vaccine is possible

Abstract

One needs to think outside of the box, as one of us (Ronald B Luftig) learned from many years as a mathematician, and a biophysicist.In this short Review, the need to focus on producing high levels of neutralizing antibodies (NAbs) to incoming and conformationally altered virus after it has bound to CD4+ cells is essential.Increasing the number of gp120 molecules on the surface of L-2 particles, could allow for an enhanced number of NAbs.The attempt at increasing CD8+ T cell responses in recent vaccine trials has not worked perhaps because it may have allowed HIV to enter into remote sanctuaries. Our approach focuses on increasing NAbs, before high levels of CD8+ T cells are produced.

Figure 1

The cartoon of the L-2 particle has 7–10 times more envelope spikes compared to HIV and shows the double membrane of immature gag. Inside the picture is a TEM image of L-2 particles.

Figure 2

Cryo-EM images: A) The L-2 images show many envelope spikes (red arrows) and a double membrane (blue arrows). B) The control HIV shows few envelope spikes and a single membrane (blue arrow).