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Comment
. 2007 Dec 20;56(6):945-6.
doi: 10.1016/j.neuron.2007.12.005.

Endocannabinoids mediate synaptic plasticity at mixed synapses

Jozsef Vigh  1 , Henrique von Gersdorff
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Endocannabinoids mediate synaptic plasticity at mixed synapses

Jozsef Vigh et al. Neuron. .
Free article

Abstract

Endocannabinoids are generally known to suppress excitatory or inhibitory synaptic transmission. Now, in an elegant series of experiments, Cachope et al. reveal a novel signaling pathway whereby endocannabinoids indirectly potentiate mixed chemical and electrical synapses. Gap junction-mediated transmission can thus be potentiated via distinct frequency-dependent mechanisms.

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