MicroRNA-155 function in B Cells
- PMID: 18093533
- DOI: 10.1016/j.immuni.2007.11.010
MicroRNA-155 function in B Cells
Abstract
Vigorito et al. (2007) report (in this issue of Immunity) that B cells require microRNA (miR)-155 for normal production of isotype-switched, high-affinity antibodies and for a memory response. They identify transcriptional regulator Pu.1 as a functionally important target of miR-155 in B cells.
Comment on
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microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells.Immunity. 2007 Dec;27(6):847-59. doi: 10.1016/j.immuni.2007.10.009. Epub 2007 Dec 6. Immunity. 2007. PMID: 18055230 Free PMC article.
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