Comment
doi: 10.1016/j.immuni.2007.12.002.
Apoptotic PS to phagocyte TIM-4: eat me
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- PMID: 18093535
- DOI: 10.1016/j.immuni.2007.12.002
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Comment
Apoptotic PS to phagocyte TIM-4: eat me
Immunity.
2007 Dec.
Free article
Abstract
Although cells dying by apoptosis expose the classical "eat me" signal phosphatidylserine (PS), a phagocytic transmembrane receptor for PS has proved elusive. Now cell and structural studies (Kobayashi et al. [2007] and Santiago et al. [2007] in this issue of Immunity) implicate the type I molecule TIM-4.
Comment on
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TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.Immunity. 2007 Dec;27(6):927-40. doi: 10.1016/j.immuni.2007.11.011. Immunity. 2007. PMID: 18082433 Free PMC article.
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