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. 2008 Feb;46(2):757-8.
doi: 10.1128/JCM.01729-07. Epub 2007 Dec 19.

Early impairment of gut function and gut flora supporting a role for alteration of gastrointestinal mucosa in human immunodeficiency virus pathogenesis

Andrea Gori  1 , Camilla Tincati, Giuliano Rizzardini, Carlo Torti, Tiziana Quirino, Monique Haarman, Kaouther Ben Amor, Jacqueline van Schaik, Aldwin Vriesema, Jan Knol, Giulia Marchetti, Gjalt Welling, Mario Clerici
Affiliations

Early impairment of gut function and gut flora supporting a role for alteration of gastrointestinal mucosa in human immunodeficiency virus pathogenesis

Andrea Gori et al. J Clin Microbiol. 2008 Feb.

Abstract

Our results show that impairment of the gastrointestinal tracts in human immunodeficiency virus (HIV)-positive patients is present in the early phases of HIV disease. This impairment is associated with alterations in gut microbiota and intestinal inflammatory parameters. These findings support the hypothesis that alterations at the gastrointestinal-tract level are a key factor in HIV pathogenesis.

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