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Comment
. 2007 Dec;14(12):1313-4.
doi: 10.1016/j.chembiol.2007.12.002.

Emetine and the alternative splicing of Bcl-X: where to next?

Jacqueline C Shultz  1 , Charles E Chalfant
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Comment

Emetine and the alternative splicing of Bcl-X: where to next?

Jacqueline C Shultz et al. Chem Biol. 2007 Dec.

Abstract

Interference with the alternative splicing of apoptotic factors offers an innovative and specific mechanism to target malignant cells. In this issue of Chemistry & Biology, Zhou et al. report on the regulation of the alternative splicing of Bcl-x pre-mRNA in response to emetine, a potent protein synthesis inhibitor, as well as define a major player in the signaling mechanism.

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