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Comment
. 2007 Dec 20;450(7173):E23; discussion E23-5.
doi: 10.1038/nature06437.

Stem cell treatment of dystrophic dogs

Allan H Bretag  1
Affiliations
Comment

Stem cell treatment of dystrophic dogs

Allan H Bretag. Nature. .

Abstract

Human muscular dystrophies are devastating and incurable inherited diseases. Hopes of progress towards therapy of muscular dystrophies were aroused when Sampaolesi et al. reported "extensive recovery of dystrophin expression, normal muscle...function", and "remarkable clinical amelioration" in golden retriever muscular dystrophy dogs treated with 'mesoangioblasts'. Here I re-examine their results, showing how their assessments might be flawed and their conclusions overstated. Further studies will be required to evaluate fully the clinical potential of this work.

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  • Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs.
    Sampaolesi M, Blot S, D'Antona G, Granger N, Tonlorenzi R, Innocenzi A, Mognol P, Thibaud JL, Galvez BG, Barthélémy I, Perani L, Mantero S, Guttinger M, Pansarasa O, Rinaldi C, Cusella De Angelis MG, Torrente Y, Bordignon C, Bottinelli R, Cossu G. Sampaolesi M, et al. Nature. 2006 Nov 30;444(7119):574-9. doi: 10.1038/nature05282. Epub 2006 Nov 15. Nature. 2006. PMID: 17108972

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