Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Jan;9(1):33-46.
doi: 10.1038/nrm2310.

Molecular architecture of the kinetochore-microtubule interface

Iain M Cheeseman  1 , Arshad Desai
Affiliations
Review

Molecular architecture of the kinetochore-microtubule interface

Iain M Cheeseman et al. Nat Rev Mol Cell Biol. 2008 Jan.

Abstract

Segregation of the replicated genome during cell division in eukaryotes requires the kinetochore to link centromeric DNA to spindle microtubules. The kinetochore is composed of a number of conserved protein complexes that direct its specification and assembly, bind to spindle microtubules and regulate chromosome segregation. Recent studies have identified more than 80 kinetochore components, and are revealing how these proteins are organized into the higher order kinetochore structure, as well as how they function to achieve proper chromosome segregation.

PubMed Disclaimer

LinkOut - more resources