doi: 10.1016/0378-4347(91)80454-k.
High-performance liquid chromatographic determination of morphine, morphine-3-glucuronide, morphine-6-glucuronide and codeine in biological samples using multi-wavelength forward optical detection
Affiliations
- PMID: 1810955
- DOI: 10.1016/0378-4347(91)80454-k
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High-performance liquid chromatographic determination of morphine, morphine-3-glucuronide, morphine-6-glucuronide and codeine in biological samples using multi-wavelength forward optical detection
J Chromatogr.
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Abstract
An isocratic high-performance liquid chromatographic method has been developed for the determination of morphine, morphine-3-glucuronide, morphine-6-glucuronide and codeine in plasma, urine and cerebrospinal fluid. The use of an efficient solid-phase extraction procedure together with a forward optical scanning detector allows a detection limit of 500 pg/ml. The method was evaluated by examination of biological samples taken from newborn infants following the intravenous administration of morphine sulfate.
Comment in
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High-performance liquid chromatographic determination of morphine, morphine-3-glucuronide, morphine-6-glucuronide and codeine in biological samples using multi-wavelength forward optical detection: a reply.J Chromatogr. 1992 Aug 7;579(1):189-90; discussion 191-2. doi: 10.1016/0378-4347(92)80380-9. J Chromatogr. 1992. PMID: 1447348 No abstract available.