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. 2008 Jan;143(1):72-8.
doi: 10.1016/j.surg.2007.07.001. Epub 2007 Dec 3.

A novel method of 2-channel dual-pulse gastric electrical stimulation improves solid gastric emptying in dogs

Geng-Qing Song  1 , Xiaohua Hou, Bin Yang, Yan Sun, Wei Qian, J D Z Chen
Affiliations

A novel method of 2-channel dual-pulse gastric electrical stimulation improves solid gastric emptying in dogs

Geng-Qing Song et al. Surgery. 2008 Jan.

Abstract

Background: Gastric electrical stimulation (GES) is known to improve vomiting with short pulses, normalize dysrhythmia with long pulses, and accelerate gastric emptying with 2 channels. The aim of this study was to assess the effects of a new method GES, namely, 2-channel GES with dual pulses on gastric emptying of solids as well as gastric dysrhythmia and emetic responses.

Methods: Seven beagle dogs implanted with 4 pairs of electrodes were studied. A novel method of GES was proposed: 2-channel dual-pulse GES in which each stimulus was composed of a short pulse followed with a long pulse, and stimulation was delivered at 2 different locations. The study was performed to test the effects of this new method of GES on vasopressin-induced delayed gastric emptying of solids, gastric dysrhythmia, and emetic responses.

Results: (1) Vasopressin-induced gastric dysrhythmia and emetic responses, as well as delayed gastric emptying of solids (P < .01). (2) Two-channel, but not 1-channel, dual-pulse GES was able to accelerate vasopressin-induced delayed gastric emptying of solids. (3) Both 1- and 2-channel dual-pulse GES was capable of improving dysrhythmia and emetic responses (P < .01).

Conclusions: The novel method of 2-channel dual-pulse GES is capable of accelerating gastric emptying of solids and improving dysrhythmia and emetic responses induced by vasopressin. This new method of GES may have a potential for gastroparesis.

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