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Case Reports
. 2007 Dec 22;335(7633):1305.
doi: 10.1136/bmj.39408.393137.BE.

Death delusion

Anders Helldén  1 , Ingegerd Odar-Cederlöf, Kajsa Larsson, Ingela Fehrman-Ekholm, Thomas Lindén
Affiliations
Case Reports

Death delusion

Anders Helldén et al. BMJ. .

Abstract

Anders Helldén and colleagues report two cases of Cotard’s syndrome that occurred as an adverse drug reaction to aciclovir and its prodrug valaciclovir

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Conflict of interest statement

Competing interests: AH has received an unrestricted grant from GlaxoSmithKline for a pharmacokinetic study.

Figures

None
Serum concentrations of aciclovir and 9-carboxymethoxymethylguanine (CMMG) in relation to neuropsychiatric symptoms and Cotard’s syndrome in case 1 (to convert values for aciclovir concentration to µg/ml, divide by 4.44; to convert values for CMMG concentrations to µg/ml, divide by 4.18)
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References

    1. Helldén A, Odar-Cederlöf I, Diener P, Barkholt L, Medin C, Svensson JO, et al. High serum concentrations of the acyclovir main metabolite 9-carboxymethoxymethylguanine in renal failure patients with acyclovir-related neuropsychiatric side effects: an observational study. Nephrol Dial Transplant 2003;18:1135-41. - PubMed
    1. Cotard J. Du délire des négations. Arch Neurol 1882;4:152-170, 282-96.
    1. Scepkowski LA, Cronin-Golomb A. The alien hand: cases, categorizations, and anatomical correlates. Behav Cogn Neurosci Rev 2003;2:261-77. - PubMed
    1. Berrios GE, Luque R. Cotard’s syndrome: analysis of 100 cases. Acta Psychiatr Scand 1995;91:185-8. - PubMed

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