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. 2007 Dec;47(12):537-42; discussion 542.
doi: 10.2176/nmc.47.537.

Effect of raloxifene on cerebral vasospasm following experimental subarachnoid hemorrhage in rats

Salih Gulsen  1 , Servet Inci, Sinan Yuruk, Umit Yasar, Tuncalp Ozgen
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Free article

Effect of raloxifene on cerebral vasospasm following experimental subarachnoid hemorrhage in rats

Salih Gulsen et al. Neurol Med Chir (Tokyo). 2007 Dec.
Free article

Abstract

The effect of raloxifene on cerebral vasospasm following experimental subarachnoid hemorrhage (SAH) was investigated in a rat model. Seven groups of seven rats underwent no SAH, no treatment; SAH only; SAH plus vehicle; SAH plus 3 days intraperitoneal raloxifene treatment; SAH plus 4 days intraperitoneal raloxifene treatment; SAH plus 3 days intrathecal raloxifene treatment; and SAH plus 4 days intrathecal raloxifene treatment. The basilar artery cross-sectional areas were measured at 72 or 96 hours following SAH. The results showed raloxifene decreased SAH-induced cerebral vasospasm in all treatment groups, and suggested no difference between intraperitoneal and intrathecal application, or between 3 days and 4 days of raloxifene treatment. The present study demonstrates that raloxifene is a potential therapeutic agent against cerebral vasospasm after SAH.

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