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Comment
. 2007 Dec 28;131(7):1228-30.
doi: 10.1016/j.cell.2007.12.007.

Template switching: from replication fork repair to genome rearrangements

Dana Branzei  1 , Marco Foiani
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Free article
Comment

Template switching: from replication fork repair to genome rearrangements

Dana Branzei et al. Cell. .
Free article

Abstract

Genome rearrangements are a hallmark of human genomic disorders and occur largely through recombination mechanisms. In this issue, Lee et al. (2007) show that the complex nonrecurrent rearrangements observed in the dysmyelinating disorder Pelizaeus-Merzbacher disease (PMD) are likely to be caused by a replication mechanism involving template switching.

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