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. 2008 Mar;15(3):534-9.
doi: 10.1128/CVI.00444-07. Epub 2007 Dec 26.

Evaluation of the antigenic relationships among canine parvovirus type 2 variants

Alessandra Cavalli  1 , Vito Martella, Costantina Desario, Michele Camero, Anna Lucia Bellacicco, Pasquale De Palo, Nicola Decaro, Gabriella Elia, Canio Buonavoglia
Affiliations

Evaluation of the antigenic relationships among canine parvovirus type 2 variants

Alessandra Cavalli et al. Clin Vaccine Immunol. 2008 Mar.

Abstract

The antigenic relationships among the original canine parvovirus type 2 (CPV-2) and the variants CPV-2a, -2b, and -2c were evaluated. Cross-antigenic evaluation revealed clear differences among the CPV variants, which were more appreciable by serum neutralization (SN) than by hemagglutination inhibition. Antigenic differences were found mostly between the original CPV-2 and the variants, but they were also observed among the variants CPV-2a, -2b, and -2c. The variant CPV-2c exhibited a unique antigenic pattern, since it was poorly recognized by the sera of animals immunized with CPV-2, CPV-2a, and CPV-2b. However, animals immunized with CPV-2c exhibited higher SN titers to CPV-2b than to the homologous virus CPV-2c. The observed antigenic differences might drive selection of CPV strains by generating differential immune pressure in the canine population, which raises concerns about vaccine efficacy.

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