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. 2008 Jan;43(1):71-4.
doi: 10.1080/03601230701735110.

Determination of cytotoxicity of nephrotoxins on murine and human kidney cell lines

Eun-Kee Park  1 , Sally K Mak, Dietmar Kültz, Bruce D Hammock
Affiliations

Determination of cytotoxicity of nephrotoxins on murine and human kidney cell lines

Eun-Kee Park et al. J Environ Sci Health B. 2008 Jan.

Abstract

The present study investigates renal inner medullary collecting duct (mIMCD3) cells and human embryonic kidney cells (HEK293) for evaluation of cytotoxicity of nephrotoxic compounds. The 24 h LC(50) values for cisplatin, paraquat and ibuprofen in mIMCD3 cells were 135, 155 and 3600 microM, respectively. The 24 h LC(50) values for paraquat and ibuprofen in HEK293 cells were 180 and 1000 microM, respectively. Effects of hyperosmolality on cytotoxicity of paraquat were additive in mIMCD3 cells. These data demonstrate that renal hyperosmolality has an additive effect on cytoxicity of paraquat.

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