doi: 10.1021/ol702846t.
Epub 2007 Dec 28.
A facile and efficient synthesis of polyfunctionalized pyridin-2(1H)-ones from beta-oxo amides under Vilsmeier conditions
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- PMID: 18161982
- DOI: 10.1021/ol702846t
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A facile and efficient synthesis of polyfunctionalized pyridin-2(1H)-ones from beta-oxo amides under Vilsmeier conditions
Org Lett.
.
Abstract
A facile and efficient one-pot synthesis of polysubstituted pyridin-2(1H)-ones from a variety of beta-oxo amides under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation and intramolecular nucleophilic cyclization is proposed.
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