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. 2008 Jan 17;10(2):345-8.
doi: 10.1021/ol702846t. Epub 2007 Dec 28.

A facile and efficient synthesis of polyfunctionalized pyridin-2(1H)-ones from beta-oxo amides under Vilsmeier conditions

Dexuan Xiang  1 , Kewei Wang, Yongjiu Liang, Guangyuan Zhou, Dewen Dong
Affiliations

A facile and efficient synthesis of polyfunctionalized pyridin-2(1H)-ones from beta-oxo amides under Vilsmeier conditions

Dexuan Xiang et al. Org Lett. .

Abstract

A facile and efficient one-pot synthesis of polysubstituted pyridin-2(1H)-ones from a variety of beta-oxo amides under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation and intramolecular nucleophilic cyclization is proposed.

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