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. 2007 Dec;5(12):e340.
doi: 10.1371/journal.pbio.0050340.

Sex, dose, and equality

Brian Oliver  1
Affiliations

Sex, dose, and equality

Brian Oliver. PLoS Biol. 2007 Dec.
No abstract available

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Figures

Figure 1
Figure 1. Network Cartoon
(A) In this simple diagram, genes (circles) and regulatory connections (lines) are shown. (B) Reducing the dose of one gene (red exclamation point) perturbs the immediately connected genes (rose), but does not collapse the network. (C) Reducing the dose of two genes result in the loss of one part of the network (red slash).
Figure 2
Figure 2. Balancing Expression
(A) With X inactivation alone, female and male gene expression is equilibrated, but X and autosome (AA) expression in both males (blue) and females (red) is not. (B) X inactivation along with increased expression from the active X chromosome balances between the sexes and between X and autosome.
Figure 3
Figure 3. Dosage Compensation in Development, with Regulation in Both Sexes
(A) Initially, X and AA expression are out of balance in both males and females. (B) The combination of increased X chromosome expression and X inactivation in females balances expression later in development.
See this image and copyright information in PMC

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