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Review
. 2008 Jan;14(1 Suppl 1):94-9.
doi: 10.1016/j.bbmt.2007.10.003.

Clinical strategies to enhance posttransplant immune reconstitution

Irwin D Bernstein  1 , Richard L Boyd, Marcel R M van den Brink
Affiliations
Review

Clinical strategies to enhance posttransplant immune reconstitution

Irwin D Bernstein et al. Biol Blood Marrow Transplant. 2008 Jan.

Erratum in

  • Biol Blood Marrow Transplant. 2008 Nov;14(11):1317-8
No abstract available

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Figures

Figure 1
Figure 1
IL-7, KGF and Donor T/NK precursors enhance post-transplant T cell reconstitution
Figure 2
Figure 2
Sex steroids are key to the degradation of the adult immune system and the immune system can be rejuvenated after re-growth of the thymus
See this image and copyright information in PMC

References

    1. Peggs KS. Immune reconstitution following stem cell transplantation. Leukemia & lymphoma. 2004;45:1093–1101. - PubMed
    1. Storek J, Gooley T, Witherspoon RP, Sullivan KM, Storb R. Infectious morbidity in long-term survivors of allogeneic marrow transplantation is associated with low CD4 T cell counts. Am J Hematol. 1997;54:131–138. - PubMed
    1. Varnum-Finney B, Xu L, Brashem-Stein C, Nourigat C, Flowers D, Bakkour S, Pear WS, Bernstein ID. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nature medicine. 2000;6:1278–1281. - PubMed
    1. Dallas MH, Varnum-Finney B, Delaney C, Kato K, Bernstein ID. Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells. The Journal of experimental medicine. 2005;201:1361–1366. - PMC - PubMed
    1. Ohishi K, Varnum-Finney B, Bernstein ID. Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(−) cord blood cells. J Clin Invest. 2002;110:1165–1174. - PMC - PubMed

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