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. 2008;23(2):135-42.
doi: 10.1007/s10654-007-9202-6. Epub 2007 Dec 28.

Apolipoprotein E gene is related to mortality only in normal weight individuals: the Rotterdam Study

M Carolina Pardo Silva  1 , A Cecile J W Janssens, Albert Hofman, Jacqueline C M Witteman, Cornelia M van Duijn
Affiliations

Apolipoprotein E gene is related to mortality only in normal weight individuals: the Rotterdam Study

M Carolina Pardo Silva et al. Eur J Epidemiol. 2008.

Abstract

Objective: To investigate the relationship between the apolipoprotein E (APOE) gene and the risk of mortality in normal weight, overweight and obese individuals.

Methods and results: In a population-based study of 7,983 individuals aged 55 years and older, we compared the risks of all-cause and coronary heart disease (CHD) mortality by APOE genotype, both overall and in subgroups defined by body mass index (BMI). We found significant evidence for interaction between APOE and BMI in relation to total cholesterol (p=0.04) and HDL cholesterol (p<0.001). Overall, APOE*2 carriers showed a decreased risk of all-cause mortality. Analyses within BMI strata showed a beneficial effect of APOE*2 only in normal weight persons (adjusted hazard ratio (HR) 0.7[95% CI 0.5-0.9]). APOE*2 was not associated with a lower risk of all-cause mortality in overweight or obese persons. The effect of APOE*2 in normal weight individuals tended to be due to the risk of CHD mortality (adjusted HR 0.5 [95% CI 0.2-1.2]).

Conclusion: The APOE*2 allele confers a lower risk of all-cause mortality only to normal weight individuals.

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Figures

Fig. 1
Fig. 1
Mean total serum cholesterol and HDL-cholesterol levels by APOE genotypes for normal weight, overweight and obese individuals. HDL: high-density lipoproteins
Fig. 2
Fig. 2
Kaplan Meier survival curves for all-cause mortality by APOE genotypes
Fig. 3
Fig. 3
Kaplan Meier survival curves for all-cause mortality by APOE genotypes for normal weight, overweight and obese individuals
See this image and copyright information in PMC

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