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Randomized Controlled Trial
. 2008 Jan;198(1):30.e1-7.
doi: 10.1016/j.ajog.2007.05.021.

Do short-term markers of treatment efficacy predict long-term sequelae of pelvic inflammatory disease?

Gail M Trautmann  1 , Kevin E Kip, Holly E Richter, David E Soper, Jeffrey F Peipert, Deborah B Nelson, Wayne Trout, Dianne Schubeck, Debra C Bass, Roberta B Ness
Affiliations
Randomized Controlled Trial

Do short-term markers of treatment efficacy predict long-term sequelae of pelvic inflammatory disease?

Gail M Trautmann et al. Am J Obstet Gynecol. 2008 Jan.

Abstract

Objective: This study was undertaken to assess whether short-term markers, often used to measure clinical cure after treatment for pelvic inflammatory disease, predict sequelae of lack of pregnancy, recurrent pelvic inflammatory disease, and chronic pelvic pain.

Study design: Women with mild-to-moderate pelvic inflammatory disease were assessed after treatment initiation at 5 days for tenderness (n = 713) and at 30 days for tenderness, cervical infections and endometritis (n = 298). Pregnancy, recurrent pelvic inflammatory disease, and chronic pelvic pain were evaluated after 84 months, on average.

Results: Pelvic tenderness at 5 and at 30 days significantly elevated the risk for developing chronic pelvic pain; tenderness at 30 days was also significantly associated with recurrent pelvic inflammatory disease. However, pelvic tenderness at 5 and at 30 days was only modestly clinically predictive of chronic pelvic pain or recurrent pelvic inflammatory disease (positive predictive values 22.1-66.9%). No short-term marker significantly influenced the likelihood of achieving a pregnancy.

Conclusion: Tenderness at 5 or 30 days did not accurately predict the occurrence of pelvic inflammatory disease-related reproductive morbidities.

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References

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