Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991;27(12):1639-42.
doi: 10.1016/0277-5379(91)90435-g.

Resistance modification by PSC-833, a novel non-immunosuppressive cyclosporin [corrected]

P R Twentyman  1 , N M Bleehen
Affiliations

Resistance modification by PSC-833, a novel non-immunosuppressive cyclosporin [corrected]

P R Twentyman et al. Eur J Cancer. 1991.

Erratum in

  • Eur J Cancer 1992;28(2-3):616

Abstract

A novel non-immunosuppressive cyclosporin [corrected], PSC-833, has been tested for its ability to circumvent resistance to doxorubicin, vincristine and colchicine in human and murine multidrug resistant (MDR) cell lines. This compound is shown to be a highly potent resistance modifier, being 7-10-fold more potent than the parent compound, cyclosporin A, whilst approximately equal to cyclosporin A in the growth inhibitory effects of compound alone. Reversal of the P-glycoprotein-associated MDR drug accumulation defect is a major component of resistance reversal for PSC-833, as it is for cyclosporin A.

PubMed Disclaimer

LinkOut - more resources