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. 1976;292(2):199-203.
doi: 10.1007/BF00498593.

Adrenal cortex adenylate cyclase. Is Ca2+ involved in ACTH stimulation?

H Glossmann, H Gips

Adrenal cortex adenylate cyclase. Is Ca2+ involved in ACTH stimulation?

H Glossmann et al. Naunyn Schmiedebergs Arch Pharmacol. 1976.

Abstract

The chelator EGTA inhibits the activation of bovine adrenal cortex adenylate cyclase by ACTH. Hormonal response is restored by addition of Ca2+, Mn2+ and other cations which are able to significantly reduce the concentration of uncomplexed EGTA in the adenylate cyclase assy medium. Time course studies reveal that the enzyme in the activated state (induced by adenylate cyclase reagents and hormone or by pretreatment with hormone) is resistant to EGTA inhibition.

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References

    1. J Biol Chem. 1974 Apr 10;249(7):2000-4 - PubMed
    1. Biochem Biophys Res Commun. 1969 Jun 6;35(5):681-6 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmacol. 1975;289(1):77-97 - PubMed
    1. Endocrinology. 1973 Mar;92(3):743-9 - PubMed
    1. J Biol Chem. 1969 Jul 10;244(13):3477-82 - PubMed

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