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. 2008 Jan 1;197(1):66-71.
doi: 10.1086/524060.

Localization of multiple quantitative trait loci influencing susceptibility to infection with Ascaris lumbricoides

Sarah Williams-Blangero  1 , John L Vandeberg, Janardan Subedi, Bharat Jha, Rodrigo Corrêa-Oliveira, John Blangero
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Localization of multiple quantitative trait loci influencing susceptibility to infection with Ascaris lumbricoides

Sarah Williams-Blangero et al. J Infect Dis. .

Abstract

A linkage-based genome scan of 1,258 members of a single pedigree of the Jirel population of Nepal localized 6 potential quantitative trait loci (QTLs) influencing susceptibility to infection with Ascaris lumbricoides, the most common soil-transmitted intestinal helminth. Three QTLs exhibited genomewide significance, including QTLs on chromosomes 13 (logarithm of the odds ratio [LOD] score, 3.37; genomewide P = .013, 8 (LOD score, 3.03; genomewide P = .031), and 11 (LOD score, 3.19; genomewide P = .020). Another QTL on chromosome 1 approached significance (LOD score, 2.72; genomewide P = .067). There was suggestive evidence of linkage for 2 additional loci on chromosomes 1 and 13.

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Comment in

  • Genes influencing susceptibility to infection.
    Petri WA Jr, Kirkpatrick BD, Haque R, Duggal P. Petri WA Jr, et al. J Infect Dis. 2008 Jan 1;197(1):4-6. doi: 10.1086/524118. J Infect Dis. 2008. PMID: 18171277 Free PMC article. No abstract available.

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