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Comment
. 2008 Jan 8;105(1):11-2.
doi: 10.1073/pnas.0710824105. Epub 2008 Jan 2.

Unraveling prion strains with cell biology and organic chemistry

Adriano Aguzzi  1
Affiliations
Comment

Unraveling prion strains with cell biology and organic chemistry

Adriano Aguzzi. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
A model for prion strain propagation and detection. PrPc (green cube) exists in equilibrium with a misfolded monomeric isoform (blue cross). The latter can assemble into structurally heterogeneous, yet highly ordered aggregated forms (upper vs. lower assemblies) that replicate differentially in select cell lines. A panel of such lines, as provided by Weissmann and colleagues, may form the basis for classifying prions. When stained with luminescent-conjugated thiophene polymers, PrPSc aggregates stemming from distinct prion strains fluoresce in different colors.
See this image and copyright information in PMC

Comment on

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