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. 1976 May;3(5):1139-49.
doi: 10.1093/nar/3.5.1139.

The mechanism of DNA strand breakage by vitamin C and superoxide and the protective roles of catalase and superoxide dismutase

A R Morgan, R L Cone, T M Elgert
Free PMC article

The mechanism of DNA strand breakage by vitamin C and superoxide and the protective roles of catalase and superoxide dismutase

A R Morgan et al. Nucleic Acids Res. 1976 May.
Free PMC article

Abstract

Vitamin C breaks DNA only in the presence of oxygen. Superoxide dismutase has no effect on the reaction but catalase suppresses it. Superoxide also gives rise to breaks in DNA suppressible by both superoxide dismutase and catalase. The hydroxyl radical seems to be the agent responsible for strand cleavage itself.

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