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. 2008 Feb 7;10(3):445-8.
doi: 10.1021/ol702739c. Epub 2008 Jan 4.

Addition of amines to nitriles catalyzed by ytterbium amides: an efficient one-step synthesis of monosubstituted N-arylamidines

Junfeng Wang  1 , Fan Xu, Tao Cai, Qi Shen
Affiliations

Addition of amines to nitriles catalyzed by ytterbium amides: an efficient one-step synthesis of monosubstituted N-arylamidines

Junfeng Wang et al. Org Lett. .

Abstract

A one-step synthesis of monosubstituted N-arylamidinates via addition of amines to nitriles catalyzed by ytterbium amides is reported. The reactions with various substrates give the products in good to excellent yields with 5 mol % ytterbium at 100 degrees C under solvent-free conditions.

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