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Review
. 2007 Oct;7(5):340-7.
doi: 10.1007/s11892-007-0056-9.

GLP-1-based therapy of type 2 diabetes: GLP-1 mimetics and DPP-IV inhibitors

Bo Ahrén  1
Affiliations
Review

GLP-1-based therapy of type 2 diabetes: GLP-1 mimetics and DPP-IV inhibitors

Bo Ahrén. Curr Diab Rep. 2007 Oct.

Abstract

Glucagon-like peptide-1 (GLP-1)-based therapy is a novel treatment for type 2 diabetes. It is executed either by GLP-1 mimetics or by dipeptidyl peptidase-IV inhibitors. In type 2 diabetes, the two strategies reduce hemoglobin A(1c) by 0.6% to 1.1% from baseline levels of 7.7% to 8.5%. They are efficient both in monotherapy and in combination with metformin or thiazolidinediones. Both treatments are well tolerated with low risk of hypoglycemia.

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