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Review
. 2008;18(1):2-14.
doi: 10.1007/s10165-007-0017-9. Epub 2008 Jan 5.

Gene therapy for arthritis

Russell S Traister  1 , Raphael Hirsch
Affiliations
Review

Gene therapy for arthritis

Russell S Traister et al. Mod Rheumatol. 2008.

Abstract

Arthritis is among the leading causes of disability in the developed world. There remains no cure for this disease and the current treatments are only modestly effective at slowing the disease's progression and providing symptomatic relief. The clinical effectiveness of current treatment regimens has been limited by short half-lives of the drugs and the requirement for repeated systemic administration. Utilizing gene transfer approaches for the treatment of arthritis may overcome some of the obstacles associated with current treatment strategies. The present review examines recent developments in gene therapy for arthritis. Delivery strategies, gene transfer vectors, candidate genes, and safety are also discussed.

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References

    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1016/j.autrev.2004.09.002', 'is_inner': False, 'url': 'https://doi.org/10.1016/j.autrev.2004.09.002'}, {'type': 'PubMed', 'value': '15823498', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/15823498/'}]}
    2. Alamanos Y, Drosos AA. Epidemiology of adult rheumatoid arthritis. Autoimmun Rev 2005;4(3):130–6. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '16273784', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/16273784/'}]}
    2. Pollard L, Choy EH, Scott DL. The consequences of rheumatoid arthritis: quality of life measures in the individual patient. Clin Exp Rheumatol 2005;23 5 Suppl 39:S43–52. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1097/00002281-200203000-00008', 'is_inner': False, 'url': 'https://doi.org/10.1097/00002281-200203000-00008'}, {'type': 'PubMed', 'value': '11845016', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/11845016/'}]}
    2. Fautrel B, Guillemin F. Cost of illness studies in rheumatic diseases. Curr Opin Rheumatol 2002;14(2):121–6. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1038/nature01661', 'is_inner': False, 'url': 'https://doi.org/10.1038/nature01661'}, {'type': 'PubMed', 'value': '12748655', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/12748655/'}]}
    2. Firestein GS. Evolving concepts of rheumatoid arthritis. Nature 2003;423(6937):356–61. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '11001373', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/11001373/'}]}
    2. Weyand CM. New insights into the pathogenesis of rheumatoid arthritis. Rheumatology (Oxford) 2000;39 Suppl 1:3–8. - PubMed

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