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Comment
. 2008 Jan;7(1):5-6.
doi: 10.1016/j.cmet.2007.12.002.

Fluxing the mitochondria to insulin resistance

Matthew J Watt  1 , Andrea L Hevener
Affiliations
Free article
Comment

Fluxing the mitochondria to insulin resistance

Matthew J Watt et al. Cell Metab. 2008 Jan.
Free article

Abstract

Elevated fatty acids promote inflammation and insulin resistance. In this issue of Cell Metabolism, Koves et al. (2008) explore a novel paradigm suggesting that beta-oxidation of fatty acids exceeding the capacity of the tricarboxylic acid cycle yields incomplete fat oxidation and mitochondrial distress, obligatory events in the pathogenesis of insulin resistance.

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