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Review
. 2008 Feb;20(1):101-6.
doi: 10.1016/j.ceb.2007.11.004. Epub 2008 Jan 4.

Structural and regulatory roles of nonmotor spindle proteins

Amity L Manning  1 , Duane A Compton
Affiliations
Review

Structural and regulatory roles of nonmotor spindle proteins

Amity L Manning et al. Curr Opin Cell Biol. 2008 Feb.

Abstract

Chromosome alignment and segregation during cell division rely on a highly ordered bipolar microtubule array called the mitotic spindle. The organization of microtubules into bipolar spindles with focused poles during mitosis requires numerous microtubule-associated proteins including both motor and nonmotor proteins. Nonmotor microtubule-associated proteins display extraordinary diversity in how they contribute to mitotic spindle organization. These mechanisms include regulation of microtubule nucleation and organization, direct and indirect influences on motor function, and control of cell cycle progression. Furthermore, many nonmotor spindle proteins display altered expression in cancer cells emphasizing their important roles in cell proliferation.

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Figures

Figure 1
Figure 1
Localization of different non-motor microtubule associated proteins during mitosis in human cells. Microtubules (green), DNA (blue) and either NuMA (A), TPX2 (B), HURP (C), or astrin (D) are shown in red.
See this image and copyright information in PMC

References

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    1. The authors using mass spectrometry to map phosphorylation sites on all major spindle-associated proteins.

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