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. 2008 Mar;52(3):1153-5.
doi: 10.1128/AAC.01351-07. Epub 2008 Jan 7.

Antimicrobial activities of Ceftaroline and ME1036 tested against clinical strains of community-acquired methicillin-resistant Staphylococcus aureus

Helio S Sader  1 , Thomas R Fritsche, Ronald N Jones
Affiliations

Antimicrobial activities of Ceftaroline and ME1036 tested against clinical strains of community-acquired methicillin-resistant Staphylococcus aureus

Helio S Sader et al. Antimicrob Agents Chemother. 2008 Mar.

Abstract

Two investigational anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) beta-lactams, ceftaroline (a cephalosporin) and ME1036 (a carbapenem), were subjected to susceptibility testing by reference broth microdilution methods using 152 strains of community-acquired MRSA from the United States (47 medical centers). Ceftaroline and ME1036 were 64- and >128-fold more potent than ceftriaxone, respectively. All isolates had the Panton-Valentine leukocidin genes and staphylococcal cassette chromosome mec type IV, while 67.8% of isolates displayed pulsed-field gel electrophoresis clonal type USA300-0114.

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References

    1. Bush, K., M. Heep, M. J. Macielag, and G. J. Noel. 2007. Anti-MRSA β-lactams in development, with a focus on ceftobiprole: the first anti-MRSA β-lactam to demonstrate clinical efficacy. Expert Opin. Investig. Drugs 16:419-429. - PubMed
    1. Clinical and Laboratory Standards Institute. 2006. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard, 7th ed. M7-A7. CLSI, Wayne, PA.
    1. Clinical and Laboratory Standards Institute. 2007. Performance standards for antimicrobial susceptibility testing: seventeenth informational supplement. M100-S17. CLSI, Wayne, PA.
    1. Deurenberg, R. H., C. Vink, S. Kalenic, A. W. Friedrich, C. A. Bruggeman, and E. E. Stobberingh. 2007. The molecular evolution of methicillin-resistant Staphylococcus aureus. Clin. Microbiol. Infect. 13:222-235. - PubMed
    1. Iizawa, Y., J. Nagai, T. Ishikawa, S. Hashiguchi, M. Nakao, A. Miyake, and K. Okonogi. 2004. In vitro antimicrobial activity of T-91825, a novel anti-MRSA cephalosporin, and in vivo anti-MRSA activity of its prodrug, TAK-599. J. Infect. Chemother. 10:146-156. - PubMed

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