doi: 10.1021/ol702825p.
Epub 2008 Jan 9.
Super silyl group for a sequential diastereoselective aldol-polyhalomethyllithium addition reaction
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- PMID: 18181637
- DOI: 10.1021/ol702825p
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Super silyl group for a sequential diastereoselective aldol-polyhalomethyllithium addition reaction
Org Lett.
.
Abstract
The super silyl group governs high diastereoselectivity and yields for a sequential aldol-polyhalomethyllithium addition reaction. This unique silyl group is necessary to obtain the diastereoselectivities associated with this sequential reaction, capable of generating two new stereocenters. Alpha-polyhalomethylcarbinols are generated with the simple and inexpensive dihalomethanes and trihalomethanes.
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