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. 2008 Jan 9:5:1.
doi: 10.1186/1743-422X-5-1.

Concurrent infections by all four dengue virus serotypes during an outbreak of dengue in 2006 in Delhi, India

Preeti Bharaj  1 , Harendra S Chahar, Anubhav Pandey, Kavita Diddi, Lalit Dar, Randeep Guleria, Sushil K Kabra, Shobha Broor
Affiliations

Concurrent infections by all four dengue virus serotypes during an outbreak of dengue in 2006 in Delhi, India

Preeti Bharaj et al. Virol J. .

Abstract

Background: Co-circulation of multiple dengue virus serotypes has been reported from many parts of the world including India, however concurrent infection with more than one serotype of dengue viruses in the same individual is rarely documented. An outbreak of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) occurred in and around Delhi in 2006. This is the first report from India with high percentage of concurrent infections with different dengue virus serotypes circulating during one outbreak.

Results: Acute phase sera from patients were tested for the presence of dengue virus RNA by RT-PCR assay. Of the 69 samples tested for dengue virus RNA, 48 (69.5%) were found to be positive. All the four dengue virus serotypes were found to be co-circulating in this outbreak with DENV-3 being the predominant serotype. In addition in 9 of 48 (19%) dengue virus positive samples, concurrent infection with more than one dengue virus serotype were identified.

Conclusion: This is the first report in which concurrent infections with different dengue virus serotypes is being reported during an outbreak from India. Delhi is now truly hyperendemic for dengue.

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Figures

Figure 1
Figure 1
Agarose gel analysis of the product from RT-PCR followed by second-round nested PCR of RNA samples. From left to right, lane 1: 100 bp molecular marker, lane 2: sample positive for DEN-2 (119 bp), lane 3: sample with concurrent infection of DEN-3 and DEN-4, lane 4: sample positive for DEN-3 (290 bp), lane 5: sample positive for DEN-4 (392 bp), lane 6: negative sample, lane 7: sample positive for DEN-4 (392 bp), lane 8: sample positive for DEN-3 (290 bp) and lane 9: negative control.
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