Review
doi: 10.1016/j.intimp.2007.06.012.
Epub 2007 Jul 19.
Angiotensin II-induced vasodilation via type 2 receptor: role of bradykinin and nitric oxide
Affiliations
- PMID: 18182246
- DOI: 10.1016/j.intimp.2007.06.012
Item in Clipboard
Review
Angiotensin II-induced vasodilation via type 2 receptor: role of bradykinin and nitric oxide
Int Immunopharmacol.
2008 Feb.
Abstract
Angiotensin II (Ang II) plays important roles in the regulation of cardiovascular functions and diseases mainly via the type 1 (AT1) receptor. In contrast, recent studies have shown that the actions of Ang II via the type 2 (AT2) receptor are counter-regulatory to those mediated via the AT1 receptor. Using an animal model of hypertension, we have demonstrated that Ang II produces a vasodilator effect through the AT2 receptor via the bradykinin (BK)-dependent activation of endothelial nitric oxide (NO) synthase. In this review, we focus on the role of BK and NO in AT2-receptor-mediated vasodilation.
Similar articles
-
Angiotensin II type 2 receptor-mediated vasodilation. Focus on bradykinin, NO and endothelium-derived hyperpolarizing factor(s).Vascul Pharmacol. 2005 Feb;42(3):109-18. doi: 10.1016/j.vph.2005.01.005. Vascul Pharmacol. 2005. PMID: 15792928 Review.
-
Nitric oxide: a physiological mediator of the type 2 (AT2) angiotensin receptor.Acta Physiol Scand. 2000 Jan;168(1):65-71. doi: 10.1046/j.1365-201x.2000.00660.x. Acta Physiol Scand. 2000. PMID: 10691781 Review.
-
Nitric oxide contributes to AT2 but not AT1 angiotensin II receptor-mediated vasodilatation of porcine pial arteries and arterioles.Eur J Pharmacol. 2005 Nov 21;525(1-3):112-6. doi: 10.1016/j.ejphar.2005.06.052. Epub 2005 Oct 27. Eur J Pharmacol. 2005. PMID: 16256981
-
Angiotensin II/AT2 receptor-induced vasodilation in stroke-prone spontaneously hypertensive rats involves nitric oxide and cGMP-dependent protein kinase.J Hypertens. 2006 Dec;24(12):2417-22. doi: 10.1097/01.hjh.0000251902.85675.7e. J Hypertens. 2006. PMID: 17082724
-
Chronic angiotensin IV treatment reverses endothelial dysfunction in ApoE-deficient mice.Cardiovasc Res. 2008 Jan;77(1):178-87. doi: 10.1093/cvr/cvm021. Epub 2007 Sep 19. Cardiovasc Res. 2008. PMID: 18006471
Cited by
-
Activation of angiotensin type 2 receptor attenuates testosterone-induced hypertension and uterine vascular resistance in pregnant rats†.Biol Reprod. 2021 Jul 2;105(1):192-203. doi: 10.1093/biolre/ioab051. Biol Reprod. 2021. PMID: 33739377 Free PMC article.
-
Developmental acceleration of bradykinin-dependent relaxation by prenatal chronic hypoxia impedes normal development after birth.Am J Physiol Lung Cell Mol Physiol. 2016 Feb 1;310(3):L271-86. doi: 10.1152/ajplung.00340.2015. Epub 2015 Dec 4. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 26637638 Free PMC article.
-
Angiotensin1-9 antagonises pro-hypertrophic signalling in cardiomyocytes via the angiotensin type 2 receptor.J Physiol. 2011 Feb 15;589(Pt 4):939-51. doi: 10.1113/jphysiol.2010.203075. Epub 2010 Dec 20. J Physiol. 2011. PMID: 21173078 Free PMC article.
-
Experimental gestational diabetes mellitus induces blunted vasoconstriction and functional changes in the rat aorta.Biomed Res Int. 2014;2014:329634. doi: 10.1155/2014/329634. Epub 2014 Dec 28. Biomed Res Int. 2014. PMID: 25610861 Free PMC article.
-
The Footprint of Kynurenine Pathway in Cardiovascular Diseases.Int J Tryptophan Res. 2022 Jun 28;15:11786469221096643. doi: 10.1177/11786469221096643. eCollection 2022. Int J Tryptophan Res. 2022. PMID: 35784899 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials
Miscellaneous
