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Randomized Controlled Trial
. 2008 Jan 12;336(7635):80-4.
doi: 10.1136/bmj.39421.435949.BE. Epub 2008 Jan 8.

Chloramphenicol versus ampicillin plus gentamicin for community acquired very severe pneumonia among children aged 2-59 months in low resource settings: multicentre randomised controlled trial (SPEAR study)

Rai Asghar  1 , Salem Banajeh, Josefina Egas, Patricia Hibberd, Imran Iqbal, Mary Katep-Bwalya, Zafarullah Kundi, Paul Law, William MacLeod, Irene Maulen-Radovan, Greta Mino, Samir Saha, Fernando Sempertegui, Jonathon Simon, Mathuram Santosham, Sunit Singhi, Donald M Thea, Shamim Qazi; Severe Pneumonia Evaluation Antimicrobial Research Study Group
Affiliations
Randomized Controlled Trial

Chloramphenicol versus ampicillin plus gentamicin for community acquired very severe pneumonia among children aged 2-59 months in low resource settings: multicentre randomised controlled trial (SPEAR study)

Rai Asghar et al. BMJ. .

Abstract

Objective: To evaluate whether five days' treatment with injectable ampicillin plus gentamicin compared with chloramphenicol reduces treatment failure in children aged 2-59 months with community acquired very severe pneumonia in low resource settings.

Design: Open label randomised controlled trial.

Setting: Inpatient wards within tertiary care hospitals in Bangladesh, Ecuador, India, Mexico, Pakistan, Yemen, and Zambia.

Participants: Children aged 2-59 months with WHO defined very severe pneumonia.

Intervention: Chloramphenicol versus a combination of ampicillin plus gentamicin.

Main outcome measures: Primary outcome measure was treatment failure at five days. Secondary outcomes were treatment failure defined similarly among all participants evaluated at 48 hours and at 10 and 21 days.

Results: More children failed treatment with chloramphenicol at day 5 (16% v 11%; relative risk 1.43, 95% confidence interval 1.03 to 1.97) and also by days 10 and 21. Overall, 112 bacterial isolates were obtained from blood and lung aspirates in 110 children (11.5%), with the most common organisms being Staphylococcus aureus (n=47) and Streptococcus pneumoniae (n=22). In subgroup analysis, bacteraemia with any organism increased the risk of treatment failure at 21 days in the chloramphenicol group (2.09, 1.41 to 3.10) but not in the ampicillin plus gentamicin group (1.12, 0.59 to 2.13). Similarly, isolation of S pneumoniae increased the risk of treatment failure at day 21 (4.06, 2.73 to 6.03) and death (5.80, 2.62 to 12.85) in the chloramphenicol group but not in the ampicillin plus gentamicin group. No difference was found in treatment failure for children with S aureus bacteraemia in the two groups, but the power to detect a difference in this subgroup analysis was low. Independent predictors of treatment failure by multivariate analysis were hypoxaemia (oxygen saturation <90%), receiving chloramphenicol, being female, and poor immunisation status.

Conclusion: Injectable ampicillin plus gentamicin is superior to injectable chloramphenicol for the treatment of community acquired very severe pneumonia in children aged 2-59 months in low resource settings.

Trial registration: Current Controlled Trials ISRCTN39543942.

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Conflict of interest statement

Competing interests: None declared.

Figures

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Fig 1 Trial profile
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Fig 2 Time to treatment failure
See this image and copyright information in PMC

Comment in

References

    1. Williams BG, Gouws E, Boschi-Pinto C, Bryce J, Dye C. Estimates of world-wide distribution of child deaths from acute respiratory infections. Lancet Infect Dis 2002;2:25-32. - PubMed
    1. Black RE, Morris SS, Bryce J. Where and why are 10 million children dying every year? Lancet 2003;361:2226-34. - PubMed
    1. WHO. World health report 2005: make every child count Geneva: WHO, 2005
    1. WHO programme for the control of acute respiratory infections. Technical basis for the WHO recommendations on the management of pneumonia in children at first level health facilities WHO/ARI/91.20. Geneva: WHO, 1991
    1. WHO. Management of the child with a serious infection or severe malnutrition: guidelines for care at the first-referral level in developing countries FCH/CAH/00.1. Geneva: WHO, 2000:1-175.

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