[The microcirculatory system in hamsters in a model of central pain syndromes]

Abstract

Experimental models of central pain syndromes, namely, trigeminal neuralgia (TN) and a pain syndrome of spinal origin, were developed in Syrian hamsters. Microhemocirculatory disorders, increased venular permeability, and increased mast cell degranulation in the mucosa of the cheek pouches were revealed. The importance of studying microcirculation in the cheek pouches of hamsters, especially in experimental TN is discussed, because appraisal of microcirculation in both pouches allows the beginning of generalization disorders to be determined.