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. 2008 Feb 7;10(3):437-40.
doi: 10.1021/ol702613f. Epub 2008 Jan 10.

Sequential Rh(I)/Pd-catalyzed 1,4-addition/intramolecular allylation: stereocontrolled construction of gamma-butyrolactones and cyclopropanes

Eric Fillion  1 , Sébastien Carret, Lauren G Mercier, Vincent E Trépanier
Affiliations

Sequential Rh(I)/Pd-catalyzed 1,4-addition/intramolecular allylation: stereocontrolled construction of gamma-butyrolactones and cyclopropanes

Eric Fillion et al. Org Lett. .

Abstract

The rhodium-catalyzed conjugate addition of functionalized vinyltin reagents to alkylidene Meldrum's acids, followed by Pd-catalyzed intramolecular allylation, is a direct entry into vinyl-substituted gamma-lactones via O-alkylation and vinylcyclopropanes via C-alkylation.

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