The two sides of hippocampal mossy fiber plasticity
- PMID: 18184559
- DOI: 10.1016/j.neuron.2007.12.015
The two sides of hippocampal mossy fiber plasticity
Abstract
Two studies in this issue of Neuron (Kwon and Castillo and Rebola et al.) show that the mossy fiber-CA3 pyramidal neuron synapse, a hippocampal synapse well known for its presynaptic plasticity, exhibits a novel form of long-term potentiation of NMDAR-mediated currents, which is induced and expressed postsynaptically.
Comment on
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Long-term potentiation selectively expressed by NMDA receptors at hippocampal mossy fiber synapses.Neuron. 2008 Jan 10;57(1):108-20. doi: 10.1016/j.neuron.2007.11.024. Neuron. 2008. PMID: 18184568 Free PMC article.
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Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses.Neuron. 2008 Jan 10;57(1):121-34. doi: 10.1016/j.neuron.2007.11.023. Neuron. 2008. PMID: 18184569
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